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It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. for SATB2 (0%), while only 3/27 (11%) lung carcinomas showed weak and focal SATB2 staining. The data generated indicate that the rabbit monoclonal anti-SATB2 has a sensitivity of 95.5% and a specificity of 85%.6 Medullary carcinoma (MC) of the colon and rectum is a rare, distinct variant of colorectal carcinoma, first described nearly 2 decades ago. Test Code SATB2 SATB2 Immunostain, Technical Component Only Advisory Information This test includes only technical performance of the stain (no pathologist interpretation is performed). The epithelial marker cytokeratin 20 (CK20) stains positive with immunohistochemistry in a vast majority of MCCs.
SATB2 is a DNA-binding protein that interacts with DNA matrix attachment regions to alter gene expression by inducing local chromatin remodeling. In contrast to TBR1, SOX5, and FEZF2, SATB2 controls the expression profiles, migration, and connectivity of intracortical projection neurons ( Fig. 6.3) ( Alcamo et al., 2008; Britanova et al., 2008 ). SATB2, when used in combination with the marker Keratin 20, may identify more than 95% of colorectal carcinoma. It may also be used to differentiate rectal neuroendocrine tumors from other neuroendocrine tumors of the gastrointestinal tract.
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SATB2 dual stain shows the greatest potential clinical utility in identifying CRC and is superior to CDX2 dual stain. More important, SATB2 dual stain could be helpful for specimens with limited tissues or those having a nonclassic staining pattern. SATB2 is a protein involved in transcription regulation and shows nuclear staining, therefore, it could have some advantages over cytoplasmic/membrane stains such as cytokeratins.
SATB2 - Avhandlingar.se
Special AT-rich sequence binding protein 2 (SATB2) is a 733–amino acid human DNA-binding protein involved in transcriptional regulation and chromatin remodeling, and its expression is restricted to glandular cells lining the lower GI tract. 22 A recent study demonstrated that SATB2 is a sensitive and highly specific marker for colorectal carcinoma (CRC) with distinct positivity in 85% of all CRCs, and SATB2 … IRES cre is expressed from the mouse Satb2 (special AT-rich sequence binding protein 2) promoter in this targeted mutant strain. When crossed with mice carrying loxP-flanked sequences of interest, floxed regions are excised in Satb2-expressing cells of the parabrachial nucleus (PBN). A nuclear localizing signal (NLS) directs expression of cre to the nucleus. Three quarters of gastric primaries stain for CDX2 and only rare examples stain for SATB2. Colorectal primaries (most of them) and appendiceal primaries (all of them) are positive for CDX2 and SATB2.
were stained for SATB2, Islet1, PAX6, TTF1, and CDX2. (1%). Focal (<5%) SATB2 staining was noted in 3 additional tumors.
stain SATB2 in epithelial cells of the appendix and neoplastic cells of the colon adenocarcinoma (tissue core 5), whereas demonstration of SATB2 in germ cells … for SATB2 (0%), while only 3/27 (11%) lung carcinomas showed weak and focal SATB2 staining.
SATB2 dual stain shows the greatest potential clinical utility in identifying CRC and is superior to CDX2 dual stain. More important, SATB2 dual stain could be helpful for specimens with limited tissues or those having a nonclassic staining pattern.
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5 Among ADCAs, previous studies of SATB2 expression in pulmonary mucinous tumors as well as gastrointestinal and pancreatobiliary adenocarcinomas are limited and/or report discordant results. 4, 5 Furthermore, to our A combination of PAX8 and SATB2 immunohistochemical stains can be used as a diagnostic tool to distinguish between these cases.